CosmoPro are the UK pioneers of Injectable Platelet Rich Fibrin (i-PRF) which is the next generation of PRP.
i-PRF offers an innovative concept to overcome previous limitations within regenerative medicine. i-PRF offers excellent cell viability and bio compatibility with superior tissue regeneration. This advanced form of platelet rich plasma does not use anticoagulants or other chemical based additives, therefore offers a completely natural treatment to improve volume loss, photo damage, fine lines and wrinkles, scars, pigmentation, poor texture and hair loss.
The low speed centrifugation concept (LSCC) guarantees a higher concentration of platelets, growth factors and leukocytes which become trapped within the fibrinogen mesh resulting in a cell rich network. These essential cells are then released slowly to lead to a natural regeneration process.
Studies prove the i-PRF Smart Cell System offers a significantly higher concentration of platelets when compared to PRP following centrifugation, which highlights the superiority of Injectable Platelet Rich Fibrin and why this system is a true game changer.
7 Fundamental growth factors are released by platelets:
EGF, PDGF, VGF, IGF, KGF, TGF-B, FGF
Platelets only release growth factors once activated.
Anticoagulant inhibits the activation of platelets
Leukocytes have a strong influence on the release of growth factors.
Leukocyte rich plasma releases larger amounts of molecules
Superior for wound healing – scars and skin needling
i-PRF Smart Cell system contains activated platelets, leukocytes (WBC) & mesenchymal stem cells
Fibrinogen is the key. The fibrin mesh traps the platelets, growth factors and bioactive molecules
i-PRF uses biocompatible medical device (class IIa) tubes specifically designed for autologous therapy
i-PRF Smart Cell system is 100% natural, completely free of chemicals, additives or clotting factors
i-PRF is an all natural autologous treatment that stimulates hair growth where hair follicles are present but inactive.
Research shows that the higher concentration of platelets, leukocytes and presence of fibrin is superior to PRP as it can enhance the growth of hair follicles by stimulating the stem cells and other cells in the microenvironment of the hair follicle.
Fibrin functions as a matrix that traps the platelets and controls their release of growth factors “very slowly and continuously over 7-10 days. Growth factors release rate into the target tissue is important for tissue receptors to respond over a prolonged period of time following treatment.
Platelets release 7 fundamental growth factors: PDGF, FGF, VEGF, EGF, KGF, IGF, TGF-β
For patients with significant hair loss, then a combined approach is often recommended, i-PRF works well for both men and women, especially those in the early stages of hair loss.
Injectable platelet‐rich fibrin stimulates greater dermal skin fibroblast cell migration, proliferation, and collagen synthesis when compared to platelet‐rich plasma.
Skin fibroblasts migrated over 350% more with i-PRF when compared to PRP (200% increase). i-PRF also significantly induces greater cell proliferation and significantly greater ability to induce collagen matrix synthesis when compared to PRP.
i-PRF yields more than double the number of platelets which play a critical role in tissue repair and regeneration, they regulate fundamental mechanisms involved in the healing process including cellular migration, proliferation, and angiogenesis.
This therapy is entirely autologous without any chemical additive and offers superior tissue bio-compatibility and tissue regeneration due to the activated platelets and fibrin matrix.
Furthermore, wound healing is drastically improved with i-PRF when compared to PRP as PRP typically contains low concentrations of leukocytes. Leukocytes are the main protagonists in wound healing and the regeneration process. Their presence in autologous therapy increases the regeneration capacity.
As the pioneers and UK specialists in i-PRF, we bring you the most advanced i-PRF training course for intimate regeneration and sexual rejuvenation.
i-PRF Intimate is a more advanced application of the traditional PRP technique which has been safely and effectively used in this specialist area.
Research shows that the higher concentration of platelets, leukocytes and presence of fibrin is superior to PRP as fibrin functions as a matrix that traps the platelets and controls their release of growth factors very slowly and continuously, to regenerate new healthy tissue. The fibrin also binds to hyaluronic acid to increase hydration and moisture levels as an alternative to non-hormonal treatments for the signs of vaginal atrophy and dyspareunia.
i-PRF Intimate is 100% natural, and suitable for men who suffer with erectile dysfunction and women who suffer with genitourinary syndrome of menopause (GSM) symptoms.
This advanced course is for medical professionals, who have completed the i-PRF Smart Cell Face & Hair training.
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» iPRF YIELDS HIGHER PLATELET COUNT THAN PRP
Anita Woolley, FIBMS. | Senior Biomedical Scientist | Sheffield Teaching Hospitals NHS Foundation Trust | STH · Sheffield Haemophilia and Thrombosis Centre |2020
» FLUID PRF (iPRF) STIMULATES GREATER DERMAL SKIN FIBROBLAST THAN PRP
Richard J Miron, Nova Southeastern University. Xuzhu Wang, The University of Hong Kong. Article in Journal of Cosmetic Dermatology · April 2019
» PRF MAY EXTEND LONGEVITY OF FAT GRAFTS
Shaoheng Xiong, M.D., Lihong Qiu, M.D., Yinjun Su, M.D., Ph.D., Hui Zheng, M.D., Chenggang Yi, M.D., Ph.D.
» ROLE OF PLATELET-RICH FIBRIN IN WOUND HEALING
Balaram Naik, P Karunakar, M Jayadev, and V Rahul Marshal
» GROWTH FACTOR MEASUREMENT AND HISTOLOGICAL ANALYSIS IN PLATELET-RICH FIBRIN
Soh Nishimoto,corresponding author Kazutoshi Fujita, Yohei Sotsuka, Masato Kinoshita, Toshihiro Fujiwara, Kenichiro Kawai, and Masao Kakibuchi
» PLATELET-RICH FIBRIN (PRF) FOR HAIR LOSS
Kian Karimi, M.D., Helena Rockwell, B.Sc.
» THE EFFECT OF PLATELET-RICH FIBRIN ON NASAL SKIN THICKNESS IN RHINOPLASTY
Sercan Gode, M.D., Arin Ozturk, M.D., Erkan Kısmalı, M.D., Veysel Berber, M.D., Goksel Turhal, M.D. | Facial Plast Surg | 2019
» EFFECT OF INJECTABLE PLATELET-RICH FIBRIN ON DICED CARTILAGE’S VIABILITY IN RHINOPLASTY
Sercan Gode, M.D., Arin Ozturk, M.D., Veysel Berber, M.D., Erkan Kısmalı, M.D. | Facial Plast Surg | 2019
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